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J Inherit Metab Dis 2014;37(4):577-85.** PMID 24789339 14 Cameron JM, Maj M, Levandovskiy V, et al

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57,61 This is attributed to (i) their NH moieties that facilitate anion binding through cooperative hydrogen bonding, (ii) the presence of multiple pyrrolic N atoms for selective chelation of metal ions, (iii) the flexible designability to adjust ion selectivity and sensitivity through varying macrocycle size and peripheral substitution, and (iv) their capacity to undergo significant color changes, including wavelength and intensity shifts in strong * absorbances when binding with ligands

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