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The function of glutamine antagonists in cancer cells is to induce intracellular hypoxia, acidosis and nutrient deprivation in cancer cells, whereas in effector T cells, glutamine antagonists promote intracellular antioxidant metabolism and induce transformation of T cells into long-lived, high-activity and high-memory subtypes

Cancer stem-like cells: metabolic architects of immune resistance Cancer stem-like cells (CSCs) are a rare but highly influential subpopulation within lung tumors that possess the hallmarks of stemnessnamely self-renewal, pluripotency, therapy resistance, and a unique ability to initiate metastasis