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Abbreviations and symbols: increase, decrease, NF-kB: Nuclear factor kappa B

Through these triple mechanisms of Nrf2-dependent redox regulation, protein interaction, and inflammatory signaling blockade, hydrogen achieves synergistic inhibition of the NF-B signaling pathway (Hu et al., 2022)

Although conclusive identification of ferroptosis in vivo is challenging, several salient and very well established features of neurodegenerative diseases are consistent with ferroptosis, including lipid peroxidation, mitochondrial disruption and iron dysregulation

Using thermal proteome profiling and chemical proteomics, we identify glutathione S-transferase P1 (GSTP1) as a previously unrecognised off-target of Molidustat and demonstrate direct inhibition of its enzymatic activity