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cerevisiae in which the ATP consuming glucose-glycogen bypass pathway had been shut-down by deletion of the GBE achieved 3.1-fold higher ATP-generating activity and 1.7-fold higher GSH productivity compared with the control strain [15]

Notably, as pivotal components of the CD4/CD8 double-negative T cell subpopulation, the antitumor activity of T cells is closely associated with IL-15 signaling pathway: IL-15 can activate surface effector molecules including NKG2D, DNAM-1, and NKp30, while promoting intracellular expression of perforin and granzyme B, ultimately augmenting this subpopulation's tumor-targeted cytolytic capacity [90]

Glutathione is a naturally occurring tripeptide composed of glutamine, cysteine, and glycine, widely recognized as a key antioxidant in cellular health research

[13] conducted a systematic review highlighting the anti-tumor activity of AST in colorectal cancer and melanoma, attributing its efficacy to the modulation of multiple molecular targets