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Quantitative endpoints, such as MRI-PDFF and histology, can capture subtle yet clinically meaningful changes, whereas ALT/AST and ultrasonography may miss early metabolic improvements

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Of all those isoenzymes, CYP2C9 accounts for the greatest proportion for metabolism of S -warfarin, which is much more potent than R -enantiomer clinically

This biological variance means that some individuals might see minimal changes, while others experience concentrated inflammation or uneven tissue degradation