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Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high-fat diet-induced obesity in mice

The peptide does not significantly cross into most other tissues

treatment of the adipocytes with the NNMT inhibitor 5-amino-1MQ resulted in a concentration-dependent increase in the NAD + levels with concentrations in the range of 160 M resulting in ~1.21.6-fold increase in NAD + levels relative to control adipocytes

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