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In addition, people that avoid animal products can be deficient in B12

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This browning is mediated through multiple pathways including SIRT1/PGC-1 activation, increased expression of thermogenic genes (UCP1, PRDM16, PPAR), and enhanced mitochondrial biogenesis

[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis