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Moreover, these sulfonamides are acting as Lewis acids with ethanol molecules, because this cosolvent is more basic than water based on their Kamlet-Taft hydrogen bond acceptor parameters reported (as = 0.75 for ethanol and 0.47 for water) (49)

Recent data shows that opioid overdose deaths involving antihistamines have increased significantly

However, the mechanistic rationale for combining these agents is sound and warrants further investigation
