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The superoxide radical generated during this process can further convert it into (O 2 ) and hydrogen peroxide (H 2 O 2 )

In fact, early in 2015, the same group suggested focusing on patients well-being and recommended using the SSRI (Sjgrens Syndrome Responder Index, a composite endpoint including five outcome measures: patient-assessed VAS scores for fatigue, oral dryness and ocular dryness, unstimulated whole salivary flow and ESR) as the primary outcome measure [85]

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The results showed that at both PreNAC and PostNAC stages, the recurrent group exhibited significant enrichment of processes related to oxidative stress resistance, including oxidative stress response and GSH metabolism