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Because of these experimental advancements, accumulating evidence suggests the paradigm that: (1) inositol 1,4,5-trisphosphate-mediated Ca 2+ release from endoplasmic reticulum causes [Ca 2+ ] i increases in astrocytes in response to the activity of adjacent astrocytes and neurons

It is important to further dissect the role of aSYN in regulating dopaminergic neurotransmission and in defining the characteristics of dopaminergic neurons, at a cellular and molecular level, that lead to their preferential neurodegeneration in PD

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N-acetylcysteine in COPD: why, how, and when