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the evidence needed to recommend one of these treatments over the other remains insufficient [140,155,157,158,178]
On the other hand, analysis of preclinical therapeutic trials in hSOD1 G93A mouse model of ALS revealed that publication bias and poorly designed experiments such as absence of randomization and blinding, lack of adequate statistical power, and variations within the animal models may lead to over reporting of false positive results (Benatar, 2008
doi:10.1161/HYPERTENSIONAHA.120.14759 Koeth RA, Wang Z, Levison BS, et al
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