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While clinical evidence remains limited, both peptides may have potential applications in supporting chondrocyte viability and potentially attenuating cartilage degradation processes associated with osteoarthritic conditions

Buffered NAD+ ships with a pH stabilizer (most commonly Tris) that brings the reconstituted solution closer to physiological pH (~7-8.5), while unbuffered NAD+ reconstitutes acidic (~pH 3-4) and is more often associated with injection-site stinging

This can lead to problems such as tiredness, weight gain and depression

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