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Although pharmacological Nrf2 activators have proven the benefits of defending against oxidative stress to prevent IDD progression in vitro and in vivo models, further investigations are needed to discover the details of the underlying molecular mechanism

It is often associated with long-term complications that can affect every system and part of the body

This include lack of consideration for the high lipid solubility of cannabis metabolites which helps them to persist in fatty tissues, therefore they may be detected in the urine weeks after the initial use ( Probable Mechanism Associated With Cannabis-Mediated Neurovascular Diseases It is evident from various studies that, consumption of cannabinoids through inhalation and combustion, is associated with the occurrence of cerebral infarcts (Wolff and Jouanjus, 2017)

This activation triggers a cascade of downstream signaling events leading to the activation of the PI3K-AKT/PKB and Ras-MAPK pathways