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Description
While both proteins markedly slow receptor desensitization and relieve the intrinsic polyamine block, they exert opposing effects on the rate of recovery from desensitization, with Neto1 accelerating and Neto2 decelerating recovery, suggesting distinct mechanisms for tuning synaptic fidelity

doi: 10.1002/jnr.20394

Although alarming, many cases are not permanent and can improve with supportive care

It achieved this at 100x lower concentration than retinoic acid, which needed 500 ppm to do the same thing