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In this review, we dissect the principal ways by which hormones can regulate circadian rhythms in target tissues as phasic drivers of physiological rhythms, as zeitgebers resetting tissue clock phase, or as tuners, affecting downstream rhythms in a more tonic fashion without affecting the core clock

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In conclusion: Melanocytic ocular neoplasia in canine and feline patients should be diagnosed as malignant versus benign (melanocytoma) with histopathology and your recommendations for adjunctive treatment and concern for metastasis should be made only after knowing cytologically what you are dealing with in each case