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Clinical treatment strategy for MTHFR-related psychiatric disorders As MTHFR plays a critical role in one-carbon metabolism, which is composed of folate, homocysteine, vitamin B12, and methylation of DNA, mutation of specific gene locus on MTHFR and correlative enzyme activity decline will affect various of physiological events as well as some pathology states, including psychiatric disorders

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Deficiencies in all of the genes responsible for overall metabolism of cobalamin are associated with various forms of methylmalonic acidemia

a second afternoon dose extends coverage