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These effects were not reproduced in 3-AR knockout mice, suggesting that the 3-AR plays a key role in the compounds chronic metabolic effects (Heffernan et al
Heart Failure with Reduced Ejection Fraction (HFrEF) is often defined by an LVEF below 40%
Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS
10.1016/j.copbio.2007.11.009
