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Senescence is characterized by a stable cell cycle arrest and multiple phenotypic changes, including the secretion of a wide array of pro-inflammatory cytokines, proteases, and other factors collectively known as the senescence-associated secretory phenotype (SASP) ( As several of the changes associated with senescence can also be observed in other cellular states, proper identification of cellular senescence requires the presence of multiple hallmarks

Moreover, the rate at which curcumin is eliminated from the body serves as another crucial determinant of its biological impacts

Moreover, treatment with EGCG enhanced endothelial function as indicated by improved brachial-artery-flow-mediated dilation [252]

doi: 10.1038/sj.bjp.0706796