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The evidence points to the involvement of NO in several features of the disease, such as bloodbrain barrier disruption, oligodendrocyte damage and demyelination, axonal degeneration, and loss of function as a result of reduced axonal conduction

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Liposomes protective effect has been attributed to their amphiphilic structure, which facilitates interaction with the skins lipid bilayer and improves the transport and release of antioxidants directly into affected cells [62]