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Description
2011;204:503.e112

In its most severe form, affected individuals have congenital anomalies, including cystic dysplastic kidneys and abnormal brain findings, and die in the newborn period of hypoglycemia, hyperammonemia, and metabolic acidosis

These results agree with those from Murali et al (23)

Nonetheless, mice with constitutive mTORC1 activity in the liver, via TSC1 deletion, display decreased AKT phosphorylation and subsequently decreased phosphorylation of FOXO1 (329, 354)
