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The learning enhancement connects to both BDNF effects (supporting synaptic plasticity) and anxiety reduction (removing the inhibitory effects of stress on new learning)

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In contrast, the social defeat stress (SDS) model was associated with optogenetic modulation of neuron projections to/from the ventromedial prefrontal cortex, ventral tegmental area, nucleus accumbens, and dorsal raphe nucleus in parallel with the PTSD clinic