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A Multicenter Study of the Effects of Vitamin B12on Sleep-Waking Rhythm Disorders: In Shizuoka Prefecture
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Doses greatly exceeding the nutritional requirements (for example, hundreds of milligrams daily) have not been studied in randomized trials for safety, so one should avoid mega doses in pregnancy unless treating a specific condition (such as pyridoxine-responsive seizures) under careful supervision
doi: 10.1038/s41598-018-22081-7 20 Aksoy SBBWardALittlePFWeinshilboumRM
