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This hydrogel showed accelerated cell migration, cell proliferation, regulated cytokines secretion from macrophages and reduction of ROS at the wound site thus enhancing wound healing

Notably, excess hemin exposure exacerbates the disease severity of SCD 19,20 and heme-scavenging strategies such as intravenous infusion of hemopexin are propective 21,22

The skin-specific mechanisms of GHK-Cu include stimulation of Type I and Type III procollagen synthesis, increased production of dermatan sulfate and other glycosaminoglycans, activation of the enzyme lysyl oxidase (which cross-links newly formed collagen), reduction of matrix metalloproteinase-1 (MMP-1, collagenase) activity, and anti-inflammatory suppression of TNF-alpha-induced IL-6 secretion

Saviano A, Apta B, Tull S, Pezhman L, Fatima A, Sevim M