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Hyperglycemia and dyslipidemia promote depressive symptoms by increasing systemic inflammation and reducing brain levels of serotonin (5-hydroxytryptamine, 5-HT) (Cai et al., 2022

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Thyroid hormone biosynthesis and regulation The hypothalamic-pituitary-thyroid axis is a self-regulatory circuit consisting of the thyroid gland, anterior pituitary gland, and hypothalamus
