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RAGE is a transmembrane receptor and is expressed in numerous tissues including ovaries, heart, lung and skeletal muscle, but also in monocytes, macrophages and lymphocytes [41]
Extracts from soursop leaves, roots, and twigs have been demonstrated to disrupt matrix metalloproteinases (MMPs), elevate reactive oxygen species (ROS), and induce G0/G1 cell cycle arrest, resulting in the inhibition of proliferation and growth of HL-60 leukemia cells [65,69,74]
Pizzorno JE, Murray MT, eds
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