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Finally, long-term safety follow-up (12 months) is essential to assess risks of chronic Nrf2 activation (e.g., cancer progression) or antioxidant interference with physiological ROS signaling, highlighted by the bardoxolone methyl experience in diabetic kidney disease (Nangaku et al., 2020)

It can be seamlessly integrated with other treatments and therapies to enhance their effectiveness

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By reducing tyrosinase activity, glutathione effectively slows down the production of new melanin, preventing the formation of additional dark spots while allowing existing pigmentation to gradually fade