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According to the monoamine hypothesis, depleted monoaminergic neurotransmitters can induce depression-like behaviors, while monoamine reuptake inhibitors can treat depression [41]

Formentini, L., Martinez-Reyes, I

- Stable gastric pentadecapeptide BPC 157 heals rat colovesical fistula - Stable gastric pentadecapeptide BPC 157 heals rectovaginal fistula in rats - Gastric pentadecapeptide BPC 157 and short bowel syndrome in rats - ncbi.nlm.nih.gov/pubmed/19093208 Cytoprotective Mechanism of the Novel Gastric Peptide BPC157 in Gastrointestinal Tract and Cultured Enteric Neurons and Glial Cells - Neuroscience Bulletin volume 35, pages167170 (2019) Esophagogastric anastomosis in rats: Improved healing by BPC 157 and L-arginine, aggravated by L-NAME - Protective effects of pentadecapeptide BPC 157 on gastric ulcer in rats - Stable Gastric Pentadecapeptide BPC 157 and Wound Healing (2021) -

As far as we know, our work is the first report of animal research on the application of NA to the treatment of DN