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10.1016/j.otohns.2009.03.020 8 ChungW

Notably, the aberrant methylation of SHOX homeobox 2 ( SHOX2 ), cysteine dioxygenase 1 ( CDO1 ), Ras association domain family member 1A ( RASSF1A ), and homeobox A7 ( HOXA7 ) genes was explored in at least three different studies

By targeting the PI3K/AKT and p53 pathways, metformin could also enhance NK cell cytotoxicity and may be used as an immunopotentiator for combination therapy with immunotherapy (Xia et al., 2020)

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