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Key limitations of the existing evidence include: Small sample sizes in many studies Heterogeneous patient populations Variable dosing regimens (typically 35 grams daily) Short follow-up periods (often 4-12 weeks) Inconsistent outcome measures Potential publication bias favouring positive results Some studies have investigated combination approaches

Arctigenin Disrupts NLRP3 Inflammasome Assembly in Colonic Macrophages via Downregulating Fatty Acid Oxidation to Prevent Colitis-Associated Cancer

[DOI] [PubMed] [Google Scholar] Collins RM, Jr, Zielke HR, Woody RC
