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Description
The nuclear segment mainly includes -catenin, which translocates to the nucleus, TCF/LEF family members, and -catenin downstream target genes, such as MMPs and c-Myc
The dose 150 mg QD was selected for the registrational study (MOXIe Part 2) because omaveloxolone displayed maximum pharmacodynamic response on most Nrf2-regulated genes (e.g., AST , CK , and GGT ) and mFARS improvement at 160 mg QD among the doses evaluated

ZitkaOSkalickovaSGumulecJMasarikMAdamVHubalekJet alRedox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

Each component is not FDA-approved and was removed from 503B bulk-compounding eligibility in 2024
