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Metabolism and Hormone Modulation Octadecanoids exert an important role in fatty acid and glucose metabolism as well as in the modulation of hormone secretion because they can activate a number of receptors linked to metabolism (e.g., PPAR, 690 TRPV1, 691 GPR40, 584 prostaglandin receptor EP3 79 )

Statistical analysis Statistical analyses were performed using GraphPad Prism (Graphpad Software, version 8.4.3) or R (version 4.5.1)

A double stranded small-interfering RNA (siRNA) to the ANGPTL3 mRNA, that is conjugated to GalNAc (identified as ARO-ANG3), has shown promise at hepatocyte-specific reduction in ANGPTL3 mRNA levels