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Abnormal oxidative damage, such as signs of lipid peroxidation, was found in biological samples and autopsy tissues from patients with sALS or fALS (Blasco et al

doi: 10.1038/sj.mp.4001629

48,49 This GSH depletion impairs the capacity of GPx4 to reduce lipid hydroperoxides and to interrupt the propagation of LPO

Numerous systematic reviews have revealed that total allostatic load is associated with an increased risk of chronic disease across the lifespan, including in childhood [159,160]
