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Abnormal oxidative damage, such as signs of lipid peroxidation, was found in biological samples and autopsy tissues from patients with sALS or fALS (Blasco et al

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doi: 10.1038/sj.mp.4001629

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48,49 This GSH depletion impairs the capacity of GPx4 to reduce lipid hydroperoxides and to interrupt the propagation of LPO

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Numerous systematic reviews have revealed that total allostatic load is associated with an increased risk of chronic disease across the lifespan, including in childhood [159,160]

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