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A probe consists of two main components: a reactive group to label reduced Cys residues in proteins coupled with an alkyne group for tagging click chemistry (Figure 4C)

GLRX2 is expressed in a range of tissues, including neurons of the mammalian brain (e.g., Padilla et al., 1992

When compared to sham-operated mice, ovariectomized animals display increased hepatic expression of hepatic insulin-degrading enzyme (IDE) and a higher C-peptide/insulin ratio after a glucose load, consistent with increased hepatic insulin clearance

The responsiveness of Arabidopsis GLRs to classical iGluR agonists and antagonists suggests partial conservation of ligand recognition logic across kingdoms