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ROS generated by mitochondria can enter the ER and trigger the unfolded protein response (UPR), which can activate three types of ER transmembrane protein receptors: Protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating transcription factor-6 (ATF-6) and inosital-requiring enzyme-1 (IRE1), which mediate three signaling pathways
Lamanna-Rama N, Romero-Miguel D, Desco M, Soto-Montenegro ML (2022) An update on the exploratory use of curcumin in neuropsychiatric disorders
& Spaeth, A
Further studies are required to fill the gaps in this field
