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Dysregulation of this axis underpins comorbidities such as heart failure-associated cognitive decline and Takotsubo cardiomyopathy, where emotional stress triggers acute cardiac dysfunction [80]
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Only 12% of an oral crystalline dose of non-protein bound vitamin B12 as occurs in fortified foods and supplements is absorbed by simple passive diffusion throughout the length of the gastrointestinal tract (Doets et al., 2013)

Mood disturbances, including irritability or depression
