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The human enzyme has been shown to possess an additional sorting signal that allows the enzyme to be segregated in the trans -Golgi network and then to the apical membrane (Wessels et al., 1990)
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For example, splicing at SS2 in neurexins modulates binding to dystroglycans, and splicing regulation at SS4 alters the affinity of neurexins for postsynaptic adhesion molecules such as neuroligins, dystroglycans, LRRTMs, calsyntenins, and latrophilins [72, 77, 79]
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