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Comparison of three synthetic transferrin mimetic small peptides to promote the blood-brain barrier penetration of vincristine liposomes for improved glioma targeted therapy

It binds to GHRH receptors in the anterior pituitary gland to stimulate the synthesis and secretion of growth hormone

Under pathological stimulation, overactivation of microglia leads to the release of large amounts of pro-inflammatory factors, ROS, and nitric oxide (NO), triggering uncontrolled inflammatory responses that ultimately result in neuronal damage and sustained neuroinflammation [68]

The peroxisome proliferator-activated receptor agonist pioglitazone prevents NF-B activation in cisplatin nephrotoxicity through the reduction of p65 acetylation via the AMPK-SIRT1/p300 pathway