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The treatment was well tolerated with no adverse events and no changes in vital signs, electrocardiograms, or laboratory markers assessing cardiac, liver, kidney, thyroid, or metabolic function

or saline 5.0 mL/kg i.p.) given at 5 min after isoprenaline, we assessed the early occlusion-like syndrome in the isoprenaline-treated rats as an early multiorgan failure (brain, heart, lung, liver, kidney and gastrointestinal lesions), thrombosis, intracranial (superior sagittal sinus) hypertension, portal and caval hypertension, and aortal hypotension, full presentation