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In healthy people, -butyrobetaine is also synthesized from the amino acid lysine, independently of the gut microbiota

GLUT1 is present in most tissues including pancreatic -cells

[77] compared the metabolic profile of CD patients intestinal mucosa (relative to the disease controls), blood plasma, and urine (relative to the healthy controls) samples using NMR spectroscopy and multivariate analysis and observed the changes in Pro, arginine (Arg), glycine (Gly), histidine (His), glutamate (Glu), aspartate (Asp), tryptophan (Trp), fumarate, formate, succinate (Succ), glycerophosphocholine (GPC) and allantoin (Alln) in the small intestinal mucosa and changes in Pro, Arg, Gly, alanine, Glu, Gln, glucose (Glc), lactate (Lac), acetate (Ace), acetoacetate (AcAc), -hydroxybutyrate (-OHB), pyruvate (Pyr), Succ, citrate (Cit), choline (Cho), creatine (Cr), phosphocreatine (PCr) and creatinine in blood plasma and changes in Pro, Trp, -OHB, Pyr, Succ, N-methylnicotinamide (NMN), aminohippurate (AHA), indoxyl sulfate (IS), and Alln in urine samples of CD patients [77]

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