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While drug expulsion from SLNs is caused by a reduction of amorphous regions in the lipid matrix due to a polymorphic transition from the less-ordered -form to the more-ordered -form, which reduces the space available for drug molecules, the drug is consequently expelled from the lipid core and may migrate to the particle surface or surrounding medium, leading to a gradual decrease in drug loading efficiency over time (Westesen et al., 1997

Ripristino dellEspressione Genica e Ringiovanimento Cellulare : Le analisi trascrittomiche rivelano che GHK-Cu pu riportare i profili di espressione genica delle cellule invecchiate a uno stato pi giovane, influenzando oltre 4.000 geni legati alla crescita cellulare, alla difesa antiossidante e alla riparazione

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Incidence of oral thrush in patients with COPD prescribed inhaled corticosteroids: Effect of drug, dose, and device