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Mitochondrial dysfunction has been implicated in the pathogenesis of MS, as studies have shown abnormalities in mitochondrial activities, metabolism, mitochondrial DNA (mtDNA) levels, and mitochondrial morphology in immune cells of individuals with MS

The brain is a highly energy-demanding organ and requires bioenergetics adaptability to balance normal activity with pathophysiologic fueling of spontaneous recurrent seizures, the hallmark feature of the epilepsies