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Moreover, administration of EC before DOX treatment significantly inhibited astrocytes activation, decreased the levels of TNF- and NO as well as reduced TNF-, NF-B and iNOS mRNA levels in brain tissues

Most MS studies utilize structural MRI for identifying lesions and determining if they are active based on gadolinium enhancement ( Materials and Methods Overview of Study Written informed consent, approved by the Institutional Review Board of Thomas Jefferson University, was obtained from all subjects and the study was registered on clinicaltrials.gov with the following identifier: NCT03032601