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Gut bacteria are known to be important in catalyzing biotransformations of certain xenobiotics, including conjugate formation with GSH (Bakke et al., 1981)

The National Academy of Medicine set no official upper limit for B12 because no clear toxicity threshold has been established in human studies B12 is extremely difficult to overdose on orally because only 1.5-2 mcg per meal is actively absorbed, and excess is excreted through the kidneys Unexpectedly high serum B12 without supplementation is a red flag that warrants medical investigation, not a sign of good health The Brasky et al

Intestinal microbiome and NAFLD: molecular insights and therapeutic perspectives

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