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Statistics Sample sizes were determined using G power 3.9.1.7 software and statistical analysis was performed using Graphpad Prism 9.4.0
Validation of qDFD11/qAAD11_1 effect using RHLs and reverse-genetic validation with TOF11 loss-of-function mutant and NILs To genotype TOF11/tof11 alleles, we developed a DNA marker to identify a 1-bp deletion at the splice site of tof11 using EcoTILLING (Hoshino et al
Through this direct targeting, miR-34a effectively downregulates SIRT1, resulting in the reactivation of p53s downstream effector p21 and promoting cell-cycle arrest in cancer cells

Twin Res Hum Genet