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Description
Gambogic acid eliminates lactylation of CNPY3, altering its localization and recruiting SIRT1, which activates caspase-1 and gasdermin D (GSDMD) through lysosomal rupture and cathepsin B (CatB) release, ultimately triggering pyroptosis in PCa cells
[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Karki P, Smith K, Johnson J, Jr, Lee E
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doi: 10.1016/j.freeradbiomed.2007.02.031
Tissue preparation for cryosectioning Dissected soleus or gastrocnemius muscle was embedded in 2%Tragacanth/1 PBS and flash-frozen for 10 s in isopentane cooled in liquid nitrogen
