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Using metabolite kinetics with the assumption that Cys and Met are the metabolites of GSH, expected concentrations of Cys and Met of above 20 and 50 M were estimated when GSH was administered at 50 mg/kg body weights every 205.4 min for Cys and 427.4 min for Met
Some protocols advocate higher loading doses up to 2.5mg daily via nasal spray, though this significantly increases peptide consumption
Other types of dispersal are due to external agents, which can be other organisms, such as animals (zoochory), or non-living vectors, such as the wind (anemochory) or water (hydrochory)
Oxidative modifications of synovial proteins contribute to the formation of neo-antigens, triggering autoimmune responses [145]
