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10.1002/adhm.202401103 52 GruberH

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The instability is most extreme when the binding of structural NADP is compromised or when the amino acid involved is at the interface between the two subunits of G6PD

Due to the lack of blood supply, once degeneration or injury occurs, the self-repair capacity of the disc is very poor, ultimately leading to clinical symptoms such as discogenic low back pain or sciatica associated with nerve compression