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After a certain period of growth to facilitate fusion, and without affecting the structure of the organoid fusion tissue, a dorsalventral forebrain axis and long-distance cell migration were established [116]

The difference in glycemic responses in different patients has also been observed (51)

However, a serious concern in targeting Wnt/-catenin pathway is the effect this may have in physiological cell renewal: additional studies are needed to assess side effects of in vivo use of the Wnt/-catenin antagonists in endometriosis