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Moreover, non-protein-bound iron may also increase the activity of iron-containing enzymes such as prolyl hydroxylase (PHD)Dependent proteasomal system 23 , which plays a key role in the degradation of hypoxia-inducible factor-1 alpha (HIF-1) 24

Furthermore, sn2-15-hydroperoxy-eicasotetraenoyl-phosphatidylethanolamines (sn2-15-HpETE-PE) generated by 15-LOX phosphatidylethanolamine binding protein-1 (PEBP1) complex can serve as a marker for ferroptosis (Shah et al., 2018)

Another class of preferred nonionic surfactants, which are used either as the sole nonionic surfactant or in combination with other nonionic surfac tants, in particular, together with alkoxylated fatty alcohols and/or alkyl glycosides, are alkoxylated, preferably ethoxylated or ethoxylated and propoxylated fatty acid alkyl esters preferably containing 1 to 4 carbon atoms in the alkyl chain, more particularly the fatty acid methyl esters which are described, for example, in Japanese Patent Application JP-A- 58/217598 or which are preferably produced by the process described in International Pa tent Application WO-A-90/13533

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