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Overall, although questions remain regarding the physiological relevance of the EnzChek substrate we recommend this assay in studies using a large volume of biological replicates

In a study of over 800 families with melanoma from southern Europe, 3.8% of families who tested negative for CDKN2A and CDK4 pathogenic variants carried POT1 variants.[48] Nine of 14 families had POT1 Ser270Asn variants
